Paper

{
  "raw_xml": "<entry>\n    <id>http://arxiv.org/abs/2603.19593v1</id>\n    <title>Widefield Nanodiamond Quantum Sensing Based on Light-Sheet Microscopy</title>\n    <updated>2026-03-20T03:11:11Z</updated>\n    <link href='https://arxiv.org/abs/2603.19593v1' rel='alternate' type='text/html'/>\n    <link href='https://arxiv.org/pdf/2603.19593v1' rel='related' title='pdf' type='application/pdf'/>\n    <summary>Nanodiamonds containing nitrogen-vacancy (NV) centers are promising quantum sensors for biological applications thanks to their sub-micron spatial resolution, biocompatibility, and versatile multi-modal responses. However, the optically detected magnetic resonance (ODMR) measurement requires laser irradiation, creating a trade-off between high-throughput and low phototoxicity for applications in live cells. Here to address this challenge we develop a widefield quantum sensing method based on light-sheet microscopy (LSM), in which the sample is illuminated by a vertically movable laser sheet and the fluorescence is collected along the vertical axis that is orthogonal to the light sheet. This LSM-ODMR system is demonstrated to feature high throughput sensing due to the wide-field configuration, fast three-dimensional imaging and sensing due to the vertical mobility of the light sheet, enhanced sensitivity due to suppression of out-of-focus background fluorescence, and low phototoxicity for bio-sensing due to elimination of out-of-focus illumination. This LSM-based widefield nanodiamond sensing provides an approach for biological studies with low phototoxicity, offering three-dimensional and multi-modal sensing capability.</summary>\n    <category scheme='http://arxiv.org/schemas/atom' term='physics.app-ph'/>\n    <category scheme='http://arxiv.org/schemas/atom' term='physics.optics'/>\n    <published>2026-03-20T03:11:11Z</published>\n    <arxiv:comment>Comments are welcome!</arxiv:comment>\n    <arxiv:primary_category term='physics.app-ph'/>\n    <author>\n      <name>Shuo Wang</name>\n    </author>\n    <author>\n      <name>Ming-Zhong Ai</name>\n    </author>\n    <author>\n      <name>Jing-Wei Fan</name>\n    </author>\n    <author>\n      <name>Junchen Ye</name>\n    </author>\n    <author>\n      <name>Chao Lin</name>\n    </author>\n    <author>\n      <name>Quan Li</name>\n    </author>\n    <author>\n      <name>Ren-Bao Liu</name>\n    </author>\n  </entry>"
}